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in Anthelmintics - 23 Apr, 2013
Albendazole recomendations

Albendazole is poorly absorbed from the gastrointestinal tract, in an unmodified form is not determined in the plasma, as rapidly converted in the liver to the primary metabolite – albendazole sulfoxide, also has anthelmintic activity. Bioavailability in Albenza is low. Admission fatty food increases the absorption and Cmax of albendazole to 5 times. Time to Cmax of albendazole sulfoxide is 2-5 hours Associated with plasma proteins is 70%. Almost completely distributed throughout the body, is found in urine, bile, hepatic cyst wall in cystic fluid, cerebrospinal fluid. Penetrates the wall of the cyst fluid and worms. Albendazole sulfoxide sulfone metabolized to albendazole (albenza, zentel) (secondary metabolite) and other oxygenated products. T1 / 2 of albendazole sulfoxide – 8-12 hours excreted in the bile through the intestines in the form of the active metabolite of albendazole sulfoxide, only a small amount is excreted in the urine. Ground clearance is not changed in patients with impaired renal function. When liver damage is increased bioavailability, with Cmax of albendazole sulfoxide is increased by 2 times, and T1 / 2 is extended. Albendazole is a microsomal enzyme inducer of cytochrome P-450 (IA); accelerates metabolism of many drugs. Pregnancy and lactation
Albenza is contraindicated during pregnancy. Before the appointment Albenza, check for pregnancy in women of childbearing age. Women of childbearing age during treatment Albenzaom recommend using non-hormonal methods of contraception.
It is not known whether it is allocated albendazole and its active metabolite in breast milk. If necessary, use Albenza during lactation should decide on the termination of breastfeeding.
Unfortunately, no one can say with certainty how long it takes for the removal of any of the toxin from the body. Elimination half-life is some kind of average value, and all of it will be different. But, if you believe the information you have applied, two days must occur almost complete removal of toxic substances.
In embryology, there is the concept of “the termination period” – that is, the period of pregnancy when the damaging factors have a maximum value. Thus, the most dangerous time for the occurrence of malformations (termination period), with a third for 8-9 weeks after fertilization. It is believed that if the embryo is exposed to the harmful effects of this time limit, or it has no effect on its further development, or (if the effect is strong enough) is a destruction of the embryo. Also, the positive role played by the fact that prior to implantation and contact with maternal blood of the embryo is in the relative “safety”. Implantation occurs about 7-9 days of development. That is, if we follow this logic, the administration of drugs with the potential teratogenic effect is best done at your specified time generic antabuse australia. If the treatment is really necessary.